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There was no dose-dependence of the doses these drugs required to produce a response, as no dose-dependent effects could be detected (Supplementary Material). No significant interaction effects were detected between the drugs that were employed and the other antidepressants of clinical relevance (Table 2).
Table 2: Comparison between all antidepressants and the used to treat major depression. Full size table
Discussion
This is the first study to assess efficacy of the combination fluoxetine and valproic acid in treating patients with depression. The in this study (N=50) were diagnosed according to DSM-IV criteria. The baseline characteristics for our study are shown as Supplementary Material online (Fig. 1). All of the patients had a clinical diagnosis of major depressive disorder, which varied from 5.
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